2J0D

Crystal structure of human P450 3A4 in complex with erythromycin

Summary for 2J0D

Entry DOI	10.2210/pdb2j0d/pdb
Related	1TQN 1W0E 1W0F 1W0G 2J0C
Descriptor	CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, ERYTHROMYCIN A, ... (4 entities in total)
Functional Keywords	polymorphism, erythromycin, monooxygenase, metal-binding, transmembrane, oxidoreductase, endoplasmic reticulum, drug metabolizing enzyme, p450, nadp, iron, heme, cyp3a4, membrane, microsome
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	112929.86
Authors	Sjogren, T.,Ekroos, M. (deposition date: 2006-08-02, release date: 2006-09-04, Last modification date: 2023-12-13)
Primary citation	Ekroos, M.,Sjogren, T. Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4 Proc.Natl.Acad.Sci.USA, 103:13682-, 2006 Cited by PubMed: 16954191 DOI: 10.1073/PNAS.0603236103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation