2V0M

Crystal structure of human P450 3A4 in complex with ketoconazole

Replaces:  2J0C

Summary for 2V0M

• Entry DOI: 10.2210/pdb2v0m/pdb
• Related: 1TQN 1W0E 1W0F 1W0G 2J0D
• Descriptor: CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE (3 entities in total)
• Functional Keywords: metal-binding, transmembrane, oxidoreductase, endoplasmic reticulum, drug metabolizing enzyme, ketoconazol, polymorphism, monooxygenase, p450, nadp, iron, heme, cyp3a4, membrane, microsome
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 4
• Total formula weight: 228643.32

Authors

Sjogren, T.,Ekroos, M. (deposition date: 2007-05-15, release date: 2007-06-26, Last modification date: 2023-12-13)

• Primary citation: Ekroos, M.,Sjogren, T.; Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4; Proc.Natl.Acad.Sci.USA, 103:13682-, 2006; PubMed: 16954191; DOI: 10.1073/PNAS.0603236103

Experimental method

X-RAY DIFFRACTION (2.8 Å)