2IWI

CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1

Summary for 2IWI

Entry DOI	10.2210/pdb2iwi/pdb
Descriptor	SERINE/THREONINE-PROTEIN KINASE PIM-2, RUTHENIUM-PYRIDOCARBAZOLE-1 (2 entities in total)
Functional Keywords	nucleotide-binding, serine/threonine-protein kinase, pim2, kinase, cancer, leukemia, transferase, atp-binding, proto-oncogene, phosphorylation
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	69593.63
Authors	Russo, S.,Debreczeni, J.E.,Amos, A.,Bullock, A.N.,Fedorov, O.,Niesen, F.,Sobott, F.,Turnbull, A.,Pike, A.C.W.,Ugochukwu, E.,Papagrigoriou, E.,Bunkoczi, G.,Gorrec, F.,Edwards, A.,Arrowsmith, C.,Weigelt, J.,Sundstrom, M.,von Delft, F.,Knapp, S. (deposition date: 2006-06-30, release date: 2006-08-02, Last modification date: 2023-12-13)
Primary citation	Bullock, A.N.,Russo, S.,Amos, A.,Pagano, N.,Bregman, H.,Debreczeni, J.E.,Lee, W.H.,von Delft, F.,Meggers, E.,Knapp, S. Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. PLoS ONE, 4:e7112-e7112, 2009 Cited by PubMed: 19841674 DOI: 10.1371/journal.pone.0007112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation