2ISL

BluB bound to reduced flavin (FMNH2) and molecular oxygen. (clear crystal form)

Summary for 2ISL

• Entry DOI: 10.2210/pdb2isl/pdb
• Related: 2ISJ 2ISK
• Descriptor: BluB, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, OXYGEN MOLECULE, ... (4 entities in total)
• Functional Keywords: flavin, oxidoreductase, monooxygenase, flavin destructase, molecular oxygen, flavoprotein
• Biological source: Sinorhizobium meliloti
• Total number of polymer chains: 8
• Total formula weight: 210485.82

Authors

Larsen, N.A.,Taga, M.E.,Howard-Jones, A.R.,Walsh, C.T.,Walker, G.C. (deposition date: 2006-10-17, release date: 2007-03-27, Last modification date: 2024-02-21)

• Primary citation: Taga, M.E.,Larsen, N.A.,Howard-Jones, A.R.,Walsh, C.T.,Walker, G.C.; BluB cannibalizes flavin to form the lower ligand of vitamin B12.; Nature, 446:449-453, 2007; PubMed: 17377583; DOI: 10.1038/nature05611

Experimental method

X-RAY DIFFRACTION (2.9 Å)