2IOG

Human estrogen receptor alpha ligand-binding domain in complex with compound 11F

Summary for 2IOG

• Entry DOI: 10.2210/pdb2iog/pdb
• Related: 2IOK
• Descriptor: Estrogen receptor, N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-[2-PHENYL-6-(2-PIPERIDIN-1-YLETHOXY)-1H-INDOL-3-YL]ACETAMIDE (3 entities in total)
• Functional Keywords: nuclear receptor, transcription factor, er-alpha, antagonist, hormone
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• Total number of polymer chains: 1
• Total formula weight: 28657.77

Authors

Fitzgerald, P.M.D.,Sharma, N. (deposition date: 2006-10-10, release date: 2007-10-09, Last modification date: 2024-02-21)

• Primary citation: Dykstra, K.D.,Guo, L.,Birzin, E.T.,Chan, W.,Yang, Y.T.,Hayes, E.C.,DaSilva, C.A.,Pai, L.-Y.,Mosley, R.T.,Kraker, B.,Fitzgerald, P.M.D.,DiNinno, F.,Rohrer, S.P.,Schaeffer, J.M.,Hammond, M.L.; Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha; Bioorg.Med.Chem.Lett., 17:2322-2328, 2007; PubMed: 17289385; DOI: 10.1016/j.bmcl.2007.01.054

Experimental method

X-RAY DIFFRACTION (1.6 Å)