2IN6

Wee1 kinase complex with inhibitor PD311839

Summary for 2IN6

• Entry DOI: 10.2210/pdb2in6/pdb
• Related: 1X8B
• Descriptor: Wee1-like protein kinase, 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID (3 entities in total)
• Functional Keywords: protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P30291
• Total number of polymer chains: 1
• Total formula weight: 32769.22

Authors

Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. (deposition date: 2006-10-05, release date: 2007-09-18, Last modification date: 2023-08-30)

• Primary citation: Smaill, J.B.,Baker, E.N.,Booth, R.J.,Bridges, A.J.,Dickson, J.M.,Dobrusin, E.M.,Ivanovic, I.,Kraker, A.J.,Lee, H.H.,Lunney, E.A.,Ortwine, D.F.,Palmer, B.D.,Quin, J.,Squire, C.J.,Thompson, A.M.,Denny, W.A.; Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.; Eur.J.Med.Chem., 43:1276-1296, 2008; PubMed: 17869387; DOI: 10.1016/j.ejmech.2007.07.016

Experimental method

X-RAY DIFFRACTION (1.9 Å)