2IAN

Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR

Summary for 2IAN

• Entry DOI: 10.2210/pdb2ian/pdb
• Related: 1KLG 1KLU 2IAL 2IAM
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, 15-mer peptide from Triosephosphate isomerase, ... (6 entities in total)
• Functional Keywords: major histocompatibility complex, t cell receptor, t cell stimulation, melanoma, tumor antigen, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Membrane; Single-pass membrane protein (Potential): P01848 P01850
• Total number of polymer chains: 20
• Total formula weight: 376776.42

Authors

Deng, L.,Langley, R.J.,Mariuzza, R.A. (deposition date: 2006-09-08, release date: 2007-04-03, Last modification date: 2023-10-25)

• Primary citation: Deng, L.,Langley, R.J.,Brown, P.H.,Xu, G.,Teng, L.,Wang, Q.,Gonzales, M.I.,Callender, G.G.,Nishimura, M.I.,Topalian, S.L.,Mariuzza, R.A.; Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor; Nat.Immunol., 8:398-408, 2007; PubMed: 17334368; DOI: 10.1038/ni1447

Experimental method

X-RAY DIFFRACTION (2.8 Å)