2I5J

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor

Summary for 2I5J

• Entry DOI: 10.2210/pdb2i5j/pdb
• Related PRD ID: PRD_900003
• Descriptor: Reverse transcriptase/ribonuclease H P66 subunit, Reverse transcriptase/ribonuclease H P51 subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: aids, hiv, reverse transcriptase, rt, rnase h inhibitor, rnhi, structure-based drug design, protein-inhibitor complex, drug resistance, transferase
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 2
• Total formula weight: 115398.26

Authors

Himmel, D.M.,Sarafianos, S.G.,Knight, J.L.,Levy, R.M.,Arnold, E. (deposition date: 2006-08-24, release date: 2006-12-05, Last modification date: 2023-08-30)

• Primary citation: Himmel, D.M.,Sarafianos, S.G.,Dharmasena, S.,Hossain, M.M.,McCoy-Simandle, K.,Ilina, T.,Clark, A.D.,Knight, J.L.,Julias, J.G.,Clark, P.K.,Krogh-Jespersen, K.,Levy, R.M.,Hughes, S.H.,Parniak, M.A.,Arnold, E.; HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.; Acs Chem.Biol., 1:702-712, 2006; PubMed: 17184135; DOI: 10.1021/cb600303y

Experimental method

X-RAY DIFFRACTION (3.15 Å)