2I1V

Crystal structure of PFKFB3 in complex with ADP and Fructose-2,6-bisphosphate

Summary for 2I1V

Entry DOI	10.2210/pdb2i1v/pdb
Related	2AXN 2DWO 2DWP
Descriptor	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, 2,6-di-O-phosphono-beta-D-fructofuranose, 6-O-phosphono-beta-D-fructofuranose, ... (6 entities in total)
Functional Keywords	ternary product complex, adp and f-2, 6-p2 in 2-kase, e-p and f-6-p in 2-pase, transferase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	60803.59
Authors	Kim, S.G.,El-Maghrabi, M.R.,Lee, Y.H. (deposition date: 2006-08-15, release date: 2007-07-03, Last modification date: 2023-10-25)
Primary citation	Kim, S.G.,Cavalier, M.,El-Maghrabi, M.R.,Lee, Y.H. A Direct Substrate-Substrate Interaction Found in the Kinase Domain of the Bifunctional Enzyme, 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase J.Mol.Biol., 370:14-26, 2007 Cited by PubMed: 17499765 DOI: 10.1016/j.jmb.2007.03.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation