2I0J

Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia

Summary for 2I0J

Entry DOI	10.2210/pdb2i0j/pdb
Related	2I0G
Descriptor	Estrogen receptor alpha, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (2 entities in total)
Functional Keywords	nuclear receptor ligand binding domain, transcription
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	4
Total formula weight	112399.71
Authors	Wang, Y. (deposition date: 2006-08-10, release date: 2006-10-24, Last modification date: 2023-08-30)
Primary citation	Norman, B.H.,Dodge, J.A.,Richardson, T.I.,Borromeo, P.S.,Lugar, C.W.,Jones, S.A.,Chen, K.,Wang, Y.,Durst, G.L.,Barr, R.J.,Montrose-Rafizadeh, C.,Osborne, H.E.,Amos, R.M.,Guo, S.,Boodhoo, A.,Krishnan, V. Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia. J.Med.Chem., 49:6155-6157, 2006 Cited by PubMed: 17034120 DOI: 10.1021/jm060491j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation