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2HXZ

Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)

Summary for 2HXZ
Entry DOI10.2210/pdb2hxz/pdb
Related2H7J
DescriptorCathepsin S, SULFATE ION, N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE, ... (4 entities in total)
Functional Keywordscathepsin s, nonpeptidic, chloromethylketone, substrate activity screening, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P25774
Total number of polymer chains3
Total formula weight74375.66
Authors
Patterson, A.W.,Wood, W.J.,Hornsby, M.,Lesley, S.,Spraggon, G.,Ellman, J.A. (deposition date: 2006-08-04, release date: 2006-10-24, Last modification date: 2023-08-30)
Primary citationPatterson, A.W.,Wood, W.J.,Hornsby, M.,Lesley, S.,Spraggon, G.,Ellman, J.A.
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
J.Med.Chem., 49:6298-6307, 2006
Cited by
PubMed: 17034136
DOI: 10.1021/jm060701s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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