2HXZ
Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)
Summary for 2HXZ
Entry DOI | 10.2210/pdb2hxz/pdb |
Related | 2H7J |
Descriptor | Cathepsin S, SULFATE ION, N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE, ... (4 entities in total) |
Functional Keywords | cathepsin s, nonpeptidic, chloromethylketone, substrate activity screening, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P25774 |
Total number of polymer chains | 3 |
Total formula weight | 74375.66 |
Authors | Patterson, A.W.,Wood, W.J.,Hornsby, M.,Lesley, S.,Spraggon, G.,Ellman, J.A. (deposition date: 2006-08-04, release date: 2006-10-24, Last modification date: 2023-08-30) |
Primary citation | Patterson, A.W.,Wood, W.J.,Hornsby, M.,Lesley, S.,Spraggon, G.,Ellman, J.A. Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method. J.Med.Chem., 49:6298-6307, 2006 Cited by PubMed: 17034136DOI: 10.1021/jm060701s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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