2HW6

Crystal structure of Mnk1 catalytic domain

Summary for 2HW6

Entry DOI	10.2210/pdb2hw6/pdb
Related	2AC3 2AC5 2HW7
Descriptor	MAP kinase-interacting serine/threonine-protein kinase 1, SULFATE ION (3 entities in total)
Functional Keywords	protein kinase, drug design, mnk1, phosphorylation, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: Q9BUB5
Total number of polymer chains	2
Total formula weight	69148.41
Authors	Jauch, R.,Wahl, M.C. (deposition date: 2006-08-01, release date: 2006-08-29, Last modification date: 2023-08-30)
Primary citation	Jauch, R.,Cho, M.K.,Netter, C.,Schreiter, K.,Aicher, B.,Zweckstetter, M.,Wahl, M.C. Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment. Embo J., 25:4020-4032, 2006 Cited by PubMed: 16917500 DOI: 10.1038/sj.emboj.7601285 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation