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2HU4

N1 neuraminidase in complex with oseltamivir 2

Summary for 2HU4
Entry DOI10.2210/pdb2hu4/pdb
Related2HT5 2HT7 2HT8 2HTQ 2HTR 2HTU 2HTV 2HTW 2HTY 2HU0
DescriptorNeuraminidase, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid (2 entities in total)
Functional Keywordsn1, neuraminidase, oseltamivir, hydrolase
Biological sourceInfluenza A virus
Cellular locationHost apical cell membrane ; Single-pass type II membrane protein : Q6DPL2
Total number of polymer chains8
Total formula weight341708.25
Authors
Russell, R.J.,Haire, L.F.,Stevens, D.J.,Collins, P.J.,Lin, Y.P.,Blackburn, G.M.,Hay, A.J.,Gamblin, S.J.,Skehel, J.J. (deposition date: 2006-07-26, release date: 2006-09-05, Last modification date: 2018-02-14)
Primary citationRussell, R.J.,Haire, L.F.,Stevens, D.J.,Collins, P.J.,Lin, Y.P.,Blackburn, G.M.,Hay, A.J.,Gamblin, S.J.,Skehel, J.J.
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.
Nature, 443:45-49, 2006
Cited by
PubMed: 16915235
DOI: 10.1038/nature05114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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