2HOC

Crystal structure of the human carbonic anhydrase II in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor

Summary for 2HOC

Entry DOI	10.2210/pdb2hoc/pdb
Related	1CA2 2HNC
Descriptor	Carbonic anhydrase 2, ZINC ION, 5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30412.71
Authors	Menchise, V.,Di Fiore, A.,De Simone, G. (deposition date: 2006-07-14, release date: 2006-10-10, Last modification date: 2023-08-30)
Primary citation	Menchise, V.,Simone, G.D.,Fiore, A.D.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II. Bioorg.Med.Chem.Lett., 16:6204-6208, 2006 Cited by PubMed: 17000110 DOI: 10.1016/j.bmcl.2006.09.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation