2HKK

Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms

Summary for 2HKK

Entry DOI	10.2210/pdb2hkk/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
Functional Keywords	carbonic anhydrase, activators, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29738.27
Authors	Temperini, C.,Innocenti, A.,Vullo, D.,Scozzafava, A.,Supuran, C.T. (deposition date: 2006-07-05, release date: 2007-05-22, Last modification date: 2023-08-30)
Primary citation	Temperini, C.,Innocenti, A.,Scozzafava, A.,Mastrolorenzo, A.,Supuran, C.T. Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. Bioorg.Med.Chem.Lett., 17:628-635, 2007 Cited by PubMed: 17127057 DOI: 10.1016/j.bmcl.2006.11.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation