2HIW

Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor

Summary for 2HIW

Entry DOI	10.2210/pdb2hiw/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, 7-AMINO-1-METHYL-3-(2-METHYL-5-{[3-(TRIFLUOROMETHYL)BENZOYL]AMINO}PHENYL)-2-OXO-2,3-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-1-IUM (3 entities in total)
Functional Keywords	kinase domain, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	2
Total formula weight	67278.69
Authors	Lee, C. (deposition date: 2006-06-29, release date: 2006-08-22, Last modification date: 2023-08-30)
Primary citation	Okram, B.,Nagle, A.,Adrian, F.J.,Lee, C.,Ren, P.,Wang, X.,Sim, T.,Xie, Y.,Wang, X.,Xia, G.,Spraggon, G.,Warmuth, M.,Liu, Y.,Gray, N.S. A general strategy for creating Chem.Biol., 13:779-786, 2006 Cited by PubMed: 16873026 DOI: 10.1016/j.chembiol.2006.05.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation