2HD6
Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.
Summary for 2HD6
| Entry DOI | 10.2210/pdb2hd6/pdb |
| Related | 1CA2 |
| Descriptor | Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total) |
| Functional Keywords | protein-inhibitor complex, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29980.90 |
| Authors | De Simone, G.,Vitale, R.M.,Di Fiore, A.,Pedone, C. (deposition date: 2006-06-20, release date: 2006-10-03, Last modification date: 2023-08-30) |
| Primary citation | De Simone, G.,Vitale, R.M.,Di Fiore, A.,Pedone, C.,Scozzafava, A.,Montero, J.L.,Winum, J.Y.,Supuran, C.T. Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J.Med.Chem., 49:5544-5551, 2006 Cited by PubMed: 16942027DOI: 10.1021/jm060531j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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