2HBT

Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor

Summary for 2HBT

• Entry DOI: 10.2210/pdb2hbt/pdb
• Related: 2HBU
• Descriptor: Egl nine homolog 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... (4 entities in total)
• Functional Keywords: prolyl hydroxylase, hypoxia inducible factor, hif, egln, 2-oxoglutarate, oxygenase, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q9GZT9
• Total number of polymer chains: 1
• Total formula weight: 28169.18

Authors

Evdokimov, A.G.,Walter, R.L.,Mekel, M.,Pokross, M.E.,Kawamoto, R.,Boyer, A. (deposition date: 2006-06-14, release date: 2006-06-27, Last modification date: 2017-10-18)

• Primary citation: Evdokimov, A.G.,Walter, R.L.,Mekel, M.,Pokross, M.E.,Kawamoto, R.,Boyer, A.; Crystal structure of HIF prolyl hydroxylase in complex with a biologically active inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)