2HAP

STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION

Summary for 2HAP

• Entry DOI: 10.2210/pdb2hap/pdb
• Descriptor: DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3'), PROTEIN (HEME ACTIVATOR PROTEIN), ... (5 entities in total)
• Functional Keywords: complex transcription factor-dna, asymmetry, transcriptional activation, hyperactive mutant, gene regulation-dna complex, gene regulation/dna
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Total number of polymer chains: 4
• Total formula weight: 31985.07

Authors

King, D.A.,Zhang, L.,Guarente, L.,Marmorstein, R. (deposition date: 1998-09-17, release date: 1999-11-10, Last modification date: 2024-02-14)

• Primary citation: King, D.A.,Zhang, L.,Guarente, L.,Marmorstein, R.; Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation.; Nat.Struct.Biol., 6:22-27, 1999; PubMed: 9886287; DOI: 10.1038/4893

Experimental method

X-RAY DIFFRACTION (2.5 Å)