2H9T

Crystal structure of human alpha-thrombin in complex with suramin

Summary for 2H9T

• Entry DOI: 10.2210/pdb2h9t/pdb
• Descriptor: Thrombin, PPACK active site thrombin inhibitor, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, ... (5 entities in total)
• Functional Keywords: thrombin, coagulation factor ii, suramin, inhibitor, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35593.53

Authors

Lima, L.M.T.R.,Polikarpov, I.,Monteiro, R.Q. (deposition date: 2006-06-11, release date: 2007-05-22, Last modification date: 2023-08-30)

• Primary citation: Lima, L.M.,Becker, C.F.,Giesel, G.M.,Marques, A.F.,Cargnelutti, M.T.,de Oliveira Neto, M.,Queiroz Monteiro, R.,Verli, H.,Polikarpov, I.; Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases.; Biochim.Biophys.Acta, 1794:873-881, 2009; PubMed: 19332154; DOI: 10.1016/j.bbapap.2009.03.011

Experimental method

X-RAY DIFFRACTION (2.4 Å)