2H96

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors

Summary for 2H96

• Entry DOI: 10.2210/pdb2h96/pdb
• Related: 2g01 2gmx
• Descriptor: Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ... (5 entities in total)
• Functional Keywords: jnk1, c-jun n-terminal kinase, protein kinase jnk1 inhibitors, pyridine carboxamide inhibitors, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm (By similarity): Q9UQF2
• Total number of polymer chains: 4
• Total formula weight: 89781.50

Authors

Abad-Zapatero, C. (deposition date: 2006-06-09, release date: 2006-07-25, Last modification date: 2023-08-30)

• Primary citation: Zhao, H.,Serby, M.D.,Xin, Z.,Szczepankiewicz, B.G.,Liu, M.,Kosogof, C.,Liu, B.,Nelson, L.T.,Johnson, E.F.,Wang, S.,Pederson, T.,Gum, R.J.,Clampit, J.E.,Haasch, D.L.,Abad-Zapatero, C.,Fry, E.H.,Rondinone, C.,Trevillyan, J.M.,Sham, H.L.,Liu, G.; Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.; J.Med.Chem., 49:4455-4458, 2006; PubMed: 16854050; DOI: 10.1021/jm060465l

Experimental method

X-RAY DIFFRACTION (3 Å)