2H7J

Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.

Summary for 2H7J

Entry DOI	10.2210/pdb2h7j/pdb
Related	2F1G
Descriptor	Cathepsin S, N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... (4 entities in total)
Functional Keywords	cathepsin s, nonpeptidic, chloromethylketone, substrate activity screening, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P25774
Total number of polymer chains	2
Total formula weight	49816.09
Authors	Patterson, A.W.,Wood, W.J.,Hornsby, M.,Lesley, S.,Spraggon, G.,Ellman, J.A. (deposition date: 2006-06-02, release date: 2006-10-24, Last modification date: 2023-08-30)
Primary citation	Patterson, A.W.,Wood, W.J.,Hornsby, M.,Lesley, S.,Spraggon, G.,Ellman, J.A. Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method. J.Med.Chem., 49:6298-6307, 2006 Cited by PubMed: 17034136 DOI: 10.1021/jm060701s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation