2H62

Crystal structure of a ternary ligand-receptor complex of BMP-2

Summary for 2H62

• Entry DOI: 10.2210/pdb2h62/pdb
• Related: 1REU 2H64
• Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, Acvr2b protein, ... (4 entities in total)
• Functional Keywords: tgf-beta superfamily, ligand-receptor complex, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P36894; Membrane; Single-pass type I membrane protein: Q3KQI1
• Total number of polymer chains: 4
• Total formula weight: 51599.28

Authors

Mueller, T.D. (deposition date: 2006-05-30, release date: 2007-04-10, Last modification date: 2024-03-13)

• Primary citation: Weber, D.,Kotzsch, A.,Nickel, J.,Harth, S.,Seher, A.,Mueller, U.,Sebald, W.,Mueller, T.D.; A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.; Bmc Struct.Biol., 7:6-6, 2007; PubMed: 17295905; DOI: 10.1186/1472-6807-7-6

Experimental method

X-RAY DIFFRACTION (1.85 Å)