2H2F

The Structural basis for Sirtuin Substrate affinity

Summary for 2H2F

• Entry DOI: 10.2210/pdb2h2f/pdb
• Descriptor: NAD-dependent deacetylase, Cellular tumor antigen p53, ZINC ION, ... (4 entities in total)
• Functional Keywords: sir2tm, hydrolase
• Biological source: Thermotoga maritima; More
• Cellular location: Cytoplasm (By similarity): Q9WYW0; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 2
• Total formula weight: 29733.69

Authors

Cosgrove, M.S.,Wolberger, C. (deposition date: 2006-05-18, release date: 2006-12-05, Last modification date: 2023-08-30)

• Primary citation: Cosgrove, M.S.,Bever, K.,Avalos, J.L.,Muhammad, S.,Zhang, X.,Wolberger, C.; The structural basis of sirtuin substrate affinity; Biochemistry, 45:7511-7521, 2006; PubMed: 16768447; DOI: 10.1021/bi0526332

Experimental method

X-RAY DIFFRACTION (2.2 Å)