2H2D
The Structural Basis for Sirtuin Substrate Affinity
Summary for 2H2D
| Entry DOI | 10.2210/pdb2h2d/pdb |
| Descriptor | NAD-dependent deacetylase, Cellular tumor antigen p53 peptide, ZINC ION, ... (4 entities in total) |
| Functional Keywords | rossmann fold, sir2, sirtuin, sir2tm, p53, sirt1, hydrolase |
| Biological source | Thermotoga maritima More |
| Cellular location | Cytoplasm : Q9WYW0 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
| Total number of polymer chains | 2 |
| Total formula weight | 29774.72 |
| Authors | Cosgrove, M.S.,Wolberger, C. (deposition date: 2006-05-18, release date: 2006-09-19, Last modification date: 2021-10-20) |
| Primary citation | Cosgrove, M.S.,Bever, K.,Avalos, J.L.,Muhammad, S.,Zhang, X.,Wolberger, C. On the Structural Basis of Sirtuin Substrate Affinity Biochemistry, 45:7511-7521, 2006 Cited by PubMed: 16768447DOI: 10.1021/bi0526332 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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