2H15
Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II
Summary for 2H15
| Entry DOI | 10.2210/pdb2h15/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total) |
| Functional Keywords | carbonic anhydrase, inhibitors, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29893.44 |
| Authors | Winum, J.Y.,Temperini, C.,Ciattini, S.,Scozzafava, A.,Supuran, C.T. (deposition date: 2006-05-16, release date: 2007-03-27, Last modification date: 2024-02-14) |
| Primary citation | Winum, J.Y.,Temperini, C.,El Cheikh, K.,Innocenti, A.,Vullo, D.,Ciattini, S.,Montero, J.L.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. J.Med.Chem., 49:7024-7031, 2006 Cited by PubMed: 17125255DOI: 10.1021/jm060807n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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