2H02

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

Summary for 2H02

• Entry DOI: 10.2210/pdb2h02/pdb
• Related: 2HO3 2HO4
• Descriptor: Protein tyrosine phosphatase, receptor type, B,, {4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (3 entities in total)
• Functional Keywords: protein tyrosine phosphatase, wpd-loop, sulfamic acid, phosphatase, inhibitor, drug design, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 73390.95

Authors

Evdokimov, A.G.,Pokross, M.E.,Walter, R.L.,Mekel, M.,Gray, J.L.,Peters, K.G.,Maier, M.B.,Amarasinghe, K.D.,Clark, C.M.,Nichols, R. (deposition date: 2006-05-13, release date: 2006-06-13, Last modification date: 2023-08-30)

• Primary citation: Amarasinghe, K.K.,Evdokimov, A.G.,Xu, K.,Clark, C.M.,Maier, M.B.,Srivastava, A.,Colson, A.O.,Gerwe, G.S.,Stake, G.E.,Howard, B.W.,Pokross, M.E.,Gray, J.L.,Peters, K.G.; Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.; Bioorg.Med.Chem.Lett., 16:4252-4256, 2006; PubMed: 16759857; DOI: 10.1016/j.bmcl.2006.05.074

Experimental method

X-RAY DIFFRACTION (2.3 Å)