2GTZ

Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A28L substitution

Summary for 2GTZ

• Entry DOI: 10.2210/pdb2gtz/pdb
• Related: 1JF1 1JHT 2GT9 2GTW 2GUO
• Descriptor: HLA-A*0201 heavy chain, Beta-2-microglobulin, octapeptide from Melan-A/MART-1, ... (6 entities in total)
• Functional Keywords: melan-a/mart-1 peptide, nonapeptide, mhc class i, hla-a2, a28l mutation, melanoma, cancer vaccines, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P61769; Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
• Total number of polymer chains: 6
• Total formula weight: 89777.79

Authors

Borbulevych, O.Y.,Baker, B.M. (deposition date: 2006-04-28, release date: 2007-06-12, Last modification date: 2023-08-30)

• Primary citation: Borbulevych, O.Y.,Insaidoo, F.K.,Baxter, T.K.,Powell, D.J.,Johnson, L.A.,Restifo, N.P.,Baker, B.M.; Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition; J.Mol.Biol., 372:1123-1136, 2007; PubMed: 17719062; DOI: 10.1016/j.jmb.2007.07.025

Experimental method

X-RAY DIFFRACTION (1.7 Å)