2GJX

Crystallographic structure of human beta-Hexosaminidase A

Summary for 2GJX

• Entry DOI: 10.2210/pdb2gjx/pdb
• Related: 2GK1
• Descriptor: Beta-hexosaminidase alpha chain, Beta-hexosaminidase beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: beta-hexosaminidase a, glycosidase, tay-sachs disease, gm2 ganglisode, tim barrel, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 472992.25

Authors

Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N.G. (deposition date: 2006-03-31, release date: 2006-06-20, Last modification date: 2020-07-29)

• Primary citation: Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N.G.; Crystallographic structure of human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 Ganglioside Hydrolysis; J.Mol.Biol., 359:913-929, 2006; PubMed: 16698036; DOI: 10.1016/j.jmb.2006.04.004

Experimental method

X-RAY DIFFRACTION (2.8 Å)