2GFS

P38 Kinase Crystal Structure in complex with RO3201195

Summary for 2GFS

• Entry DOI: 10.2210/pdb2gfs/pdb
• Descriptor: Mitogen-Activated Protein Kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE (3 entities in total)
• Functional Keywords: p38; map kinase; serine/threonine kinase, signaling protein, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q16539
• Total number of polymer chains: 1
• Total formula weight: 43120.08

Authors

Harris, S.F.,Bertrand, J.,Villasenor, A. (deposition date: 2006-03-23, release date: 2006-04-18, Last modification date: 2024-02-14)

• Primary citation: Goldstein, D.M.,Alfredson, T.A.,Bertrand, J.,Browner, M.F.,Clifford, K.,Dalrymple, S.,Dunn, J.,Freire-Moare, J.,Harris, S.F.,Labadie, S.S.,La Fargue, J.,Lapierre, J.M.,Larrabee, S.,Li, F.,Papp, E.,McWeeney, D.,Ramesha, C.,Roberts, R.,Rotstein, D.,San Pablo, B.,Sjogren, E.,So, O.Y.,Talamas, F.X.,Tao, W.,Trejo, A.,Villasenor, A.,Welch, M.,Welch, T.,Weller, P.,Whiteley, P.E.,Young, K.,Zipfel, S.; Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]-methanone (RO3201195), and Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase; J.Med.Chem., 49:1562-1575, 2006; PubMed: 16509574; DOI: 10.1021/jm050736c

Experimental method

X-RAY DIFFRACTION (1.752 Å)