2GFO

Structure of the Catalytic Domain of Human Ubiquitin Carboxyl-terminal Hydrolase 8

Summary for 2GFO

Entry DOI	10.2210/pdb2gfo/pdb
Related	1WHB 2A9U 2FZP
Descriptor	Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION (3 entities in total)
Functional Keywords	hydrolase, protease, thiol protease, ubl conjugation pathway, deubiquitinating enzyme, dub, zinc ribbon, structural genomics consortium, sgc
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P40818
Total number of polymer chains	1
Total formula weight	45718.34
Authors	Walker, J.R.,Avvakumov, G.V.,Xue, S.,Newman, E.M.,Finerty Jr., P.J.,Butler-Cole, C.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.,Edwards, A.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2006-03-22, release date: 2006-04-04, Last modification date: 2018-01-24)
Primary citation	Avvakumov, G.V.,Walker, J.R.,Xue, S.,Finerty Jr., P.J.,Mackenzie, F.,Newman, E.M.,Dhe-Paganon, S. Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8). J.Biol.Chem., 281:38061-38070, 2006 Cited by PubMed: 17035239 DOI: 10.1074/jbc.M606704200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation