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2GDZ

Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+

Summary for 2GDZ
Entry DOI10.2210/pdb2gdz/pdb
DescriptorNAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
Functional Keywordshydroxyprostaglandin, dehydrogenase, structural genomics, short-chain dehydrogenase/reductase, inflammation, structural genomics consortium, sgc, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P15428
Total number of polymer chains1
Total formula weight29842.96
Authors
Pilka, E.S.,Guo, K.,Kavanagh, K.,Von Delft, F.,Arrowsmith, C.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2006-03-17, release date: 2006-04-04, Last modification date: 2023-10-25)
Primary citationNiesen, F.H.,Schultz, L.,Jadhav, A.,Bhatia, C.,Guo, K.,Maloney, D.J.,Pilka, E.S.,Wang, M.,Oppermann, U.,Heightman, T.D.,Simeonov, A.
High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One, 5:e13719-e13719, 2010
Cited by
PubMed: 21072165
DOI: 10.1371/journal.pone.0013719
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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