2GDZ
Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+
Summary for 2GDZ
Entry DOI | 10.2210/pdb2gdz/pdb |
Descriptor | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total) |
Functional Keywords | hydroxyprostaglandin, dehydrogenase, structural genomics, short-chain dehydrogenase/reductase, inflammation, structural genomics consortium, sgc, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15428 |
Total number of polymer chains | 1 |
Total formula weight | 29842.96 |
Authors | Pilka, E.S.,Guo, K.,Kavanagh, K.,Von Delft, F.,Arrowsmith, C.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2006-03-17, release date: 2006-04-04, Last modification date: 2023-10-25) |
Primary citation | Niesen, F.H.,Schultz, L.,Jadhav, A.,Bhatia, C.,Guo, K.,Maloney, D.J.,Pilka, E.S.,Wang, M.,Oppermann, U.,Heightman, T.D.,Simeonov, A. High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships. Plos One, 5:e13719-e13719, 2010 Cited by PubMed: 21072165DOI: 10.1371/journal.pone.0013719 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report