2GDO

4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors

Summary for 2GDO

Entry DOI	10.2210/pdb2gdo/pdb
Descriptor	Serine/threonine-protein kinase Chk1, SULFATE ION, 4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE, ... (4 entities in total)
Functional Keywords	drug design, atp-binding, cell cycle, dna damage, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	34483.89
Authors	Le, V.,Dove, J.,Fang, E.,Bussiere, D.E. (deposition date: 2006-03-16, release date: 2007-03-20, Last modification date: 2024-02-14)
Primary citation	Ni, Z.J.,Barsanti, P.,Brammeier, N.,Diebes, A.,Poon, D.J.,Ng, S.,Pecchi, S.,Pfister, K.,Renhowe, P.A.,Ramurthy, S.,Wagman, A.S.,Bussiere, D.E.,Le, V.,Zhou, Y.,Jansen, J.M.,Ma, S.,Gesner, T.G. 4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors. Bioorg.Med.Chem.Lett., 16:3121-3124, 2006 Cited by PubMed: 16603354 DOI: 10.1016/j.bmcl.2006.03.059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation