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2G9K

Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-2',3,3',4',5-Pentachlorobiphenyl

Summary for 2G9K
Entry DOI10.2210/pdb2g9k/pdb
DescriptorTransthyretin, 2',3,3',4',5-PENTACHLOROBIPHENYL-4-OL (3 entities in total)
Functional Keywordsttr, amyloid, transthyretin, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28239.58
Authors
Palaninathan, S.K.,Smith, C.,Safe, S.H.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2006-03-06, release date: 2006-03-14, Last modification date: 2023-08-30)
Primary citationPurkey, H.E.,Palaninathan, S.K.,Kent, K.C.,Smith, C.,Safe, S.H.,Sacchettini, J.C.,Kelly, J.W.
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity
Chem.Biol., 11:1719-1728, 2004
Cited by
PubMed: 15610856
DOI: 10.1016/j.chembiol.2004.10.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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