2G72

Structure of hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoMet

Summary for 2G72

Entry DOI	10.2210/pdb2g72/pdb
Related	1HNN 1N7I 1N7J 1YZ3 2g70 2g71
Descriptor	Phenylethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE, (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, ... (4 entities in total)
Functional Keywords	methyltransferase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	65149.69
Authors	Tyndall, J.D.A.,Gee, C.L.,Martin, J.L. (deposition date: 2006-02-27, release date: 2007-02-13, Last modification date: 2023-10-25)
Primary citation	Gee, C.L.,Drinkwater, N.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50:4845-4853, 2007 Cited by PubMed: 17845018 DOI: 10.1021/jm0703385 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation