2FV5

Crystal structure of TACE in complex with IK682

Summary for 2FV5

• Entry DOI: 10.2210/pdb2fv5/pdb
• Related: 1bkc 2ddf
• Descriptor: ADAM 17, ZINC ION, (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE, ... (4 entities in total)
• Functional Keywords: tace adam17 zn-endopeptidase, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P78536
• Total number of polymer chains: 2
• Total formula weight: 59759.49

Authors

Orth, P.,Niu, X. (deposition date: 2006-01-30, release date: 2006-07-04, Last modification date: 2023-08-30)

• Primary citation: Niu, X.,Umland, S.,Ingram, R.,Beyer, B.M.,Liu, Y.H.,Sun, J.,Lundell, D.,Orth, P.; IK682, a tight binding inhibitor of TACE.; Arch.Biochem.Biophys., 451:43-50, 2006; PubMed: 16762314; DOI: 10.1016/j.abb.2006.03.034

Experimental method

X-RAY DIFFRACTION (2.1 Å)