2FUM

Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone

Summary for 2FUM

• Entry DOI: 10.2210/pdb2fum/pdb
• Related: 1O6Y
• Descriptor: Probable serine/threonine-protein kinase pknB, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE (2 entities in total)
• Functional Keywords: protein kinase-inhibitor complex, transferase
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 4
• Total formula weight: 131611.95

Authors

Wehenkel, A.,Alzari, P.M. (deposition date: 2006-01-27, release date: 2006-08-01, Last modification date: 2023-10-25)

• Primary citation: Wehenkel, A.,Fernandez, P.,Bellinzoni, M.,Catherinot, V.,Barilone, N.,Labesse, G.,Jackson, M.,Alzari, P.M.; The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria; Febs Lett., 580:3018-3022, 2006; PubMed: 16674948; DOI: 10.1016/j.febslet.2006.04.046

Experimental method

X-RAY DIFFRACTION (2.89 Å)