2FQQ

Crystal structure of human caspase-1 (Cys285->Ala, Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 1-methyl-3-trifluoromethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (2-mercapto-ethyl)-amide

Summary for 2FQQ

Entry DOI	10.2210/pdb2fqq/pdb
Related	1sc1 1sc3 1sc4 2FQR 2FQS 2FQU 2FQV
Descriptor	Caspase-1, 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE, ... (4 entities in total)
Functional Keywords	caspase, allosteric inhibitor, hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P29466 P29466
Total number of polymer chains	2
Total formula weight	30309.66
Authors	Scheer, J.M.,Wells, J.A.,Romanowski, M.J. (deposition date: 2006-01-18, release date: 2006-05-16, Last modification date: 2023-08-30)
Primary citation	Scheer, J.M.,Romanowski, M.J.,Wells, J.A. A common allosteric site and mechanism in caspases Proc.Natl.Acad.Sci.USA, 103:7595-7600, 2006 Cited by PubMed: 16682620 DOI: 10.1073/pnas.0602571103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation