2FP7

West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H

2FP7 の概要

• エントリーDOI: 10.2210/pdb2fp7/pdb
• 関連するPDBエントリー: 2FOM
• 関連するBIRD辞書のPRD_ID: PRD_000988
• 分子名称: Genome polyprotein, N-benzoyl-L-norleucyl-L-lysyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-argininamide, ... (4 entities in total)
• 機能のキーワード: flavivirus, ns3 protease, ns2b cofactor, substrate-based inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: West Nile virus (WNV); 詳細
• 細胞内の位置: Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side : P06935 P06935
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 25353.52

構造登録者

Schiering, N.,D'Arcy, A.,Erbel, P. (登録日: 2006-01-16, 公開日: 2006-03-07, 最終更新日: 2024-04-03)

• 主引用文献: Erbel, P.,Schiering, N.,D'Arcy, A.,Renatus, M.,Kroemer, M.,Lim, S.P.,Yin, Z.,Keller, T.H.,Vasudevan, S.G.,Hommel, U.; Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.; Nat.Struct.Mol.Biol., 13:372-373, 2006; PubMed: 16532006; DOI: 10.1038/nsmb1073

実験手法

X-RAY DIFFRACTION (1.68 Å)