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2FKL

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP)

Summary for 2FKL
Entry DOI10.2210/pdb2fkl/pdb
Related1OWT 2FJZ 2FK1 2FK2 2FK3
DescriptorAmyloid beta A4 protein precursor (2 entities in total)
Functional Keywordsalpha-beta two-layered sandwich, metal binding protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P05067
Total number of polymer chains2
Total formula weight15177.61
Authors
Kong, G.K.-W.,Parker, M.W. (deposition date: 2006-01-04, release date: 2007-01-16, Last modification date: 2023-08-30)
Primary citationKong, G.K.,Adams, J.J.,Harris, H.H.,Boas, J.F.,Curtain, C.C.,Galatis, D.,Masters, C.L.,Barnham, K.J.,McKinstry, W.J.,Cappai, R.,Parker, M.W.
Structural Studies of the Alzheimer's Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions
J.Mol.Biol., 367:148-161, 2007
Cited by
PubMed: 17239395
DOI: 10.1016/j.jmb.2006.12.041
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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