2FGB
Crystal structure of human 17bet a-hydroxysteroid dehydrogenase type 5 in complexes with PEG and NADP
Summary for 2FGB
| Entry DOI | 10.2210/pdb2fgb/pdb |
| Descriptor | Aldo-keto reductase family 1 member C3, ACETATE ION, HEXAETHYLENE GLYCOL, ... (5 entities in total) |
| Functional Keywords | (alpha/beta)8 barrel, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P42330 |
| Total number of polymer chains | 1 |
| Total formula weight | 37980.99 |
| Authors | Qiu, W.,Zhou, M.,Azzi, A.,Luu-The, V.,Labrie, F.,Lin, S.X. (deposition date: 2005-12-21, release date: 2006-12-12, Last modification date: 2024-02-14) |
| Primary citation | Qiu, W.,Zhou, M.,Mazumdar, M.,Azzi, A.,Ghanmi, D.,Luu-The, V.,Labrie, F.,Lin, S.X. Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 282:8368-8379, 2007 Cited by PubMed: 17166832DOI: 10.1074/jbc.M606784200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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