2F7X

Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine

Summary for 2F7X

• Entry DOI: 10.2210/pdb2f7x/pdb
• Related: 1YDS 2F7E 2F7Z
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, PKI, inhibitory peptide, (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE, ... (4 entities in total)
• Functional Keywords: protein kinase a, akt inhibitors, transferase
• Biological source: Bos taurus (cattle)
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43274.51

Authors

Li, Q.,Li, T.,Zhu, G.D.,Gong, J.,Claibone, A.,Dalton, C.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Bauch, J.L.,Marsh, K.C.,Bouska, J.J.,Arries, S.,De Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L. (deposition date: 2005-12-01, release date: 2006-06-27, Last modification date: 2024-02-14)

• Primary citation: Li, Q.,Li, T.,Zhu, G.D.,Gong, J.,Claibone, A.,Dalton, C.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Bauch, J.L.,Marsh, K.C.,Bouska, J.J.,Arries, S.,De Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L.; Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.; Bioorg.Med.Chem.Lett., 16:1679-1685, 2006; PubMed: 16403626; DOI: 10.1016/j.bmcl.2005.12.017

Experimental method

X-RAY DIFFRACTION (1.9 Å)