2F70

Protein tyrosine phosphatase 1B with sulfamic acid inhibitors

Summary for 2F70

Entry DOI	10.2210/pdb2f70/pdb
Related	2F6T 2F6V 2F6W 2F6Y 2F71 2F7Z
Descriptor	Tyrosine-protein phosphatase, non-receptor type 1, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	ptp1b, sulfamic acids, tetrahydroisoquinoline, phosphatase, tyrosine, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35316.15
Authors	Evdokimov, A.G.,Pokross, M.E.,Klopfenstein, S.R. (deposition date: 2005-11-29, release date: 2005-12-13, Last modification date: 2023-08-23)
Primary citation	Klopfenstein, S.R.,Evdokimov, A.G.,Colson, A.-O.,Fairweather, N.T.,Neuman, J.J.,Maier, M.B.,Gray, J.L.,Gerwe, G.S.,Stake, G.E.,Howard, B.W.,Farmer, J.A.,Pokross, M.E.,Downs, T.R.,Kasibhatla, B.,Peters, K.G. 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors Bioorg.Med.Chem.Lett., 16:1574-1578, 2006 Cited by PubMed: 16386905 DOI: 10.1016/j.bmcl.2005.12.051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation