2F53

Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity

Summary for 2F53

• Entry DOI: 10.2210/pdb2f53/pdb
• Related: 2F54
• Descriptor: HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ... (8 entities in total)
• Functional Keywords: t-cell receptor, cdr2, phage display, mutant, high affinity, ny-eso-1, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Cytoplasm: P78358
• Total number of polymer chains: 5
• Total formula weight: 93672.14

Authors

Rizkallah, P.J.,Jakobsen, B.K.,Dunn, S.M.,Sami, M. (deposition date: 2005-11-25, release date: 2006-04-25, Last modification date: 2023-08-23)

• Primary citation: Dunn, S.M.,Rizkallah, P.J.,Baston, E.,Mahon, T.,Cameron, B.,Moysey, R.,Gao, F.,Sami, M.,Boulter, J.,Li, Y.,Jakobsen, B.K.; Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.; Protein Sci., 15:710-721, 2006; PubMed: 16600963; DOI: 10.1110/ps.051936406

Experimental method

X-RAY DIFFRACTION (2.1 Å)