2F2U

crystal structure of the Rho-kinase kinase domain

Summary for 2F2U

Entry DOI	10.2210/pdb2f2u/pdb
Descriptor	Rho-associated protein kinase 2, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (3 entities in total)
Functional Keywords	enzyme-inhibitor complex, transferase
Biological source	Bos taurus (cattle)
Cellular location	Cytoplasm: Q28021
Total number of polymer chains	2
Total formula weight	92134.78
Authors	Yamaguchi, H.,Hakoshima, T. (deposition date: 2005-11-18, release date: 2006-04-25, Last modification date: 2023-10-25)
Primary citation	Yamaguchi, H.,Kasa, M.,Amano, M.,Kaibuchi, K.,Hakoshima, T. Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil Structure, 14:589-600, 2006 Cited by PubMed: 16531242 DOI: 10.1016/j.str.2005.11.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation