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2EXL

GRP94 N-terminal Domain bound to geldanamycin

Summary for 2EXL
Entry DOI10.2210/pdb2exl/pdb
Related1QY5 1TBW 1TC6 1U20 1YT1 2ESA
DescriptorEndoplasmin, GELDANAMYCIN, TETRAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywordsgrp94, gp96, hsp90, bergerat fold, chaperone, endoplasmic reticulum, geldanamycin, 17-aag
Biological sourceCanis lupus familiaris (dog)
More
Cellular locationEndoplasmic reticulum lumen: P41148
Total number of polymer chains2
Total formula weight55164.48
Authors
Reardon, P.N.,Immormino, R.M.,Gewirth, D.T. (deposition date: 2005-11-08, release date: 2006-10-24, Last modification date: 2023-08-23)
Primary citationImmormino, R.M.,Metzger, L.E.,Reardon, P.N.,Dollins, D.E.,Blagg, B.S.,Gewirth, D.T.
Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
J.Mol.Biol., 388:1033-1042, 2009
Cited by
PubMed: 19361515
DOI: 10.1016/j.jmb.2009.03.071
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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