2ETZ

The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide

Summary for 2ETZ

• Entry DOI: 10.2210/pdb2etz/pdb
• Related: 1LUI 1LUK 1LUM 1LUN 2EU0
• Descriptor: Tyrosine-protein kinase ITK/TSK, Lymphocyte cytosolic protein 2 phosphopeptide fragment (2 entities in total)
• Functional Keywords: cis/trans isomerization, interleukin-2 tyrosine kinase, itk, t-cell specific kinase, tsk, src homology 2, sh2, proline, phosphotyrosine binding, transferase
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cell membrane: Q03526; Cytoplasm (Probable): Q60787
• Total number of polymer chains: 2
• Total formula weight: 13354.97

Authors

Sundd, M.,Pletneva, E.V.,Fulton, D.B.,Andreotti, A.H. (deposition date: 2005-10-27, release date: 2006-02-07, Last modification date: 2022-03-09)

• Primary citation: Pletneva, E.V.,Sundd, M.,Fulton, D.B.,Andreotti, A.H.; Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide.; J.Mol.Biol., 357:550-561, 2006; PubMed: 16436281; DOI: 10.1016/j.jmb.2005.12.073

Experimental method

SOLUTION NMR