2EC9

Crystal structure analysis of human Factor VIIa , Souluble tissue factor complexed with BCX-3607

Summary for 2EC9

• Entry DOI: 10.2210/pdb2ec9/pdb
• Related: 1DAN
• Descriptor: Coagulation factor VII, Tissue factor, 1,5-anhydro-D-glucitol, ... (9 entities in total)
• Functional Keywords: protein-cofactor complex, fviia and souluble tissue factor, inhibitor, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 68084.69

Authors

Raman, K.,Yarlagadda, B. (deposition date: 2007-02-13, release date: 2008-02-19, Last modification date: 2023-11-15)

• Primary citation: Krishnan, R.,Kotian, P.L.,Chand, P.,Bantia, S.,Rowland, S.,Babu, Y.S.; Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.; Acta Crystallogr.,Sect.D, 63:689-697, 2007; PubMed: 17505107; DOI: 10.1107/S0907444907014187

Experimental method

X-RAY DIFFRACTION (2 Å)