2E6D
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with fumarate
Summary for 2E6D
Entry DOI | 10.2210/pdb2e6d/pdb |
Related | 2DJL 2DJX 2E68 2E6A 2E6F |
Descriptor | Dihydroorotate dehydrogenase, COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, ... (6 entities in total) |
Functional Keywords | chagas disease, pyrimidine biosynthesis, dihydroorotate dehydrogenase, fumarate reductase, energy metabolism, redox homeostasis, flavoprotein, oxidoreductase |
Biological source | Trypanosoma cruzi |
Cellular location | Cytoplasm (By similarity): Q4D3W2 |
Total number of polymer chains | 2 |
Total formula weight | 70163.28 |
Authors | Inaoka, D.K.,Shimizu, H.,Sakamoto, K.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Harada, S.,Kita, K. (deposition date: 2006-12-26, release date: 2008-01-15, Last modification date: 2023-11-15) |
Primary citation | Inaoka, D.K.,Sakamoto, K.,Shimizu, H.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Kita, K.,Harada, S. Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction Biochemistry, 47:10881-10891, 2008 Cited by PubMed: 18808149DOI: 10.1021/bi800413r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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