2E6D

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with fumarate

Summary for 2E6D

Entry DOI	10.2210/pdb2e6d/pdb
Related	2DJL 2DJX 2E68 2E6A 2E6F
Descriptor	Dihydroorotate dehydrogenase, COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
Functional Keywords	chagas disease, pyrimidine biosynthesis, dihydroorotate dehydrogenase, fumarate reductase, energy metabolism, redox homeostasis, flavoprotein, oxidoreductase
Biological source	Trypanosoma cruzi
Cellular location	Cytoplasm (By similarity): Q4D3W2
Total number of polymer chains	2
Total formula weight	70163.28
Authors	Inaoka, D.K.,Shimizu, H.,Sakamoto, K.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Harada, S.,Kita, K. (deposition date: 2006-12-26, release date: 2008-01-15, Last modification date: 2023-11-15)
Primary citation	Inaoka, D.K.,Sakamoto, K.,Shimizu, H.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Kita, K.,Harada, S. Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction Biochemistry, 47:10881-10891, 2008 Cited by PubMed: 18808149 DOI: 10.1021/bi800413r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation