2E3K

Crystal structure of the human Brd2 second bromodomain in complexed with the acetylated histone H4 peptide

Summary for 2E3K

• Entry DOI: 10.2210/pdb2e3k/pdb
• Related: 2DVV
• Descriptor: Bromodomain-containing protein 2, 15-mer peptide from Histone H4 (3 entities in total)
• Functional Keywords: bromodomain, binds to acetylated histone tails, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (By similarity): P25440; Nucleus: P02309
• Total number of polymer chains: 6
• Total formula weight: 55481.63

Authors

Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-11-27, release date: 2007-12-11, Last modification date: 2023-11-15)

• Primary citation: Padmanabhan, B.,Umehara, T.,Nakano, K.,Jang, M.K.,Ozato, K.,Yokohama, S.; Structural basis for diacetylated histone H4 tail recognition by the second bromodomain of human BRD2; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)